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Not all patients with CLL need therapy. Irrespective of all recent improvements, the iwCLL even now endorses watchful observation for patients with asymptomatic illness.86 This recommendation is predicated on a minimum of two randomized trials comparing observation to possibly chlorambucil monotherapy or fludarabine, cyclophosphamide and rituximab (FCR).103,104 Both equally trials concluded that early therapy in asymptomatic clients was not connected with a prolonged All round survival.
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